I just bought Dreamfall off GOG. It seems to be in working order otherwise, but mouse buttons don't do jacks**t when I'm in combat mode. This is weird, because they do work elsewhere in the game. The assigned keys for attacks do work, but it's not the way I want to play.
My OS is a 32 bit Vista, and the mouse is a part of logitech keyboard/mouse wireless combo connected to a USB port. It's a standard run-of-the-mill 3-button mouse with a scrollwheel as a middle button.
Any suggestions? Are there any settings I could tinker with?